Best Probiotic Supplements to Take in 2022 [Backed By Studies]

Ever since I was in my mid-20s, I was accompanied by a weak stomach and lousy digestion. This often left me with a cranky attitude, especially during family gatherings. I always seemed to have a frown on my face. Also, I used to keep my problems to myself until my family doctor tried to diagnose me one night.

He quickly concluded that the microbes in my digestive tract were out of balance. I have started researching the best probiotic supplements that could relieve my issues. Fortunately, after hours of surfing through medical forums, I found some promising brands.

I was surprised to find out how they benefited me in more ways than one. And if digestive issues have got you down, you will find my list reviews pretty advantageous. So, stick around and read on!

The Top Probiotic Supplements in 2022

I know how daunting it can be to find the perfect supplements brand for probiotics. Hence, I put together a list of top probiotic supplements in my article today.

  • BioFit
  • 1MD Complete Probiotics
  • BioTrust Pro-X10
  • BiOptimizers P3-OM
  • Organifi Balance
  • LeanBiome
  • Nucific Bio-X4
  • ActivatedYou Advanced Restorative Probiotic
  • Gundry MD 24 Strain Probiotic
  • Unify Health Labs Multi-GI 5
  • Seed Daily Synbiotic
  • JustThrive Probiotic & Antioxidant
  • VitaPost Probiotic 40-Billion
  • Live Conscious Pro-45
  • Probiotic T-50
  • Nuzena Probiotic 40 Gut Boost +
  • UpWellness Probiotic+
  • Prime Health Daily Probiotic Balance
  • Oweli Probiotic
  • Earth Echo Probiotic
  • Earth Echo Vitality Bliss Bites
  • Probulin
  • Microbiome Plus+
  • Revival Point FloraSpring
  • Probiotic America Perfect Biotics
  • Advanced BioNutritionals Advanced Probiotic Formula
  • Simple Promise Ovuna
  • Vital Plan Biome Boost
  • ProBio-Lite
  • Orthobiome
  • Organixx Probiotixx +
  • PhytAge Labs Replenish 911
  • Vital Plan Advanced Biotic



The first probiotic supplement on this list comes with multiple health benefits and can improve gut health. This is not just one of those regular probiotic supplements. It has reportedly helped several consumers to lose a significant amount of weight. Further, it’s one of the best sleep aids, including some health-enhancing bonuses.

BioFit is one of the few sleeping aids that induce weight loss in men and women. Moreover, it serves as an ally for those struggling to lose weight. They also included a few weight loss recipe books and a box of pills. These recipes will help you maintain a diet and make your weight loss journey easier.

I have conducted significant research on this particular product, which shed some light on its mind-blowing results. Many of its users have reported losing up to 72 pounds with regular doses of this probiotic. Daily consumption of this supplement will also allow you to sleep within a short time.

Highlighted Features

  • You can lose up to 72 pounds of weight
  • Backed by several years of research
  • Includes weight loss recipe books as a bonus
  • Supports healthy gut

1MD Complete Probiotics


There are plenty of probiotics that don’t show any noticeable effects despite their power. That’s because most of those probiotics are eliminated by the acid in our stomach. The manufacturers of this supplement found a solution to this and modified their probiotics to be more efficient.

After several years of research and experiments, this company has made delayed-release capsules that release the probiotics in your bloodstream after a specific time. This allows your intestines to absorb most of the probiotics in the supplement. 1MD Complete Probiotics is significantly more beneficial for those suffering from stomach pain.

Digestive issues can often be the main reason for sleep deprivation. The supplement makes it easier for you to sleep by taking care of these issues. Moreover, the sleeping aid contains 51 billion CFUs per serving. The powerful probiotics are also available in 11 different strains to improve digestion and sleep.

Highlighted Features

  • 51 billion CFUs per serving
  • It consists of 11 strains of probiotics
  • Increases absorption rate
  • Delayed-release capsules

BioTrust Pro-X10


Poor intestinal health can often lead to weakness and irritation in daily life. Taking probiotics as this works, a weight-loss supplement can help you reach your targeted bodyweight much faster. This highly efficient probiotic tackles many of the drawbacks of sleep deprivation and grants you a good night’s sleep.

BioTrust Pro-X10 can also remove harmful bacteria strains from your gut that cause stress or irritation. This eventually enhances your mood and helps you go through your day-to-day activities with a positive attitude. People that often suffer from abdominal pain might also find this product helpful.

On top of that, several strains of probiotics are included in this supplement that can provide relief from multiple health problems. With the best probiotics at your disposal, you will be sleeping peacefully. This probiotic supplementation also comes at a more reasonable price than others.

Highlighted Features

  • It helps you maintain a positive attitude
  • Allows you to reach your targeted bodyweight
  • Removes harmful bacteria
  • Keeps you active

BiOptimizers P3-OM


Instead of looking for supplements that just support digestion, why not look for a product with a range of other benefits? I have included a product just like that at number 4. BiOptimizers P3-OM will help you sleep better, remove brain fog, and give you a long-lasting energy boost.

Now you can tackle your daily life problems without worrying about clouded judgment or suffering from weakness. These dietary supplements are also suitable for people who like to exercise as they offer quick muscle recovery. It helps you lose fat much faster and also improves lean muscle growth.

This is also an efficient way of getting rid of gas in your stomach, which can often cause bloating. It is one of the few supplements on this list containing prebiotic and probiotic ingredients. They are present in an equal amount to ensure the gut microbiome work at optimal levels.

The highly efficient prebiotic supplement can also protect you from harmful pathogens and germs that can cause different diseases.

Highlighted Features

  • Removes brain fog
  • It gives you more energy all-day
  • Promotes lean muscle growth
  • Removes gas from your stomach

Organifi Balance


Organifi is one of the pioneers of probiotic supplements that have been in the business for several years now. Their balanced formulated probiotics are the latest and best products, which come with five potent strains and offer 20 billion colony-forming units per serving.

What sets Organifi apart from other probiotic manufacturers is its utmost transparency. They always allow users to see all the available ingredients in their products, proving their reliability. This makes it one of the most potent probiotics on the list.

Furthermore, Organifi Balance is capable of diversifying gut flora and improving your health. With regular dosage, you will notice reduced bloating after a particular time. The supplement is available in the Jerusalem artichoke form, which enhances the efficiency of healthy gut bacteria present in your gut.

It also helps you get rid of physical discomfort and sleep better at night.

Highlighted Features

  • They are transparent about their ingredients
  • Available in Jerusalem artichoke form
  • It contains five-strong bacterial strains of probiotics
  • Delivers 20 billion colony forming units per serving



Several studies online show how a healthy gut can increase your chances of losing weight. Many of you have tried several exercises and diets and still failed to lose fat. This is the exact supplement you have been looking for all these days, as it can keep you from ingesting more calories than you need.

The probiotics in LeanBiome reduce food cravings, which can help you maintain a strict weight loss diet. You won’t have to suffer from a cranky mood due to the lack of food. The supplement can get rid of stubborn fat in your body. It also enhances your metabolism and stops your body from storing fat.

You can also diversify your gut flora by ingesting probiotic supplements regularly. This will take care of your distressed stomach and gas, which often hinder a good night’s sleep. The supplement contains proven ingredients such as Lactobacillus fermentum, Lactobacillus gasseri, and Lactobacillus rhamnosus.

It also comes with a Greenselect Phytosome that prevents fat from permanently setting in your gut or the rest of your body.

Highlighted Features

  • It helps you lose weight much faster
  • Enhances metabolism
  • Decreases food cravings
  • Contains Greenselect Phytosome

Nucific Bio-X4


At number 7, I am reviewing an exclusive probiotic supplement that doesn’t just allow you to shed weight but also prevents your body from gaining more weight. It contains a combination of proven ingredients that can eliminate cravings and enhance your metabolism. Also, it can tackle weight gain in a variety of ways.

Nucific Bio-X4 has four primary active ingredients that support healthy digestion and relieve stress. Although this supplement is specially made for achieving weight loss goals, it also allows you to sleep better. It can also recover poor digestion in your intestines, getting rid of distress.

Moreover, its main ingredients include prebiotics and probiotics, digestive enzymes, and green tea extract. These live microorganisms are proven to improve digestive health and promote weight loss. This serves as a one-stop solution for sleep deprivation and seemingly unstoppable weight gain.

Highlighted Features

  • It stops you from gaining weight
  • Relieves stress from your gut
  • A perfect blend of probiotics and prebiotics
  • It contains digestive enzymes and green tea extract

ActivatedYou Advanced Restorative Probiotic


ActivatedYou Advanced Restorative Probiotic is a class apart because of its state-of-the-art formula and range of additional benefits. It is the only sleeping aid on this list with 30 different bacterial strains. You won’t find this level of diversity in any other probiotic supplement on the market.

The Advanced Restorative Probiotic can boost your immune system, which will protect you from disease-causing bacteria. It is mainly used to remove discomfort in your stomach and optimize your digestive system. Further, it also balances out your body from the inside out.

After starting the dose, you might also notice your skin glowing with joy. It keeps you in a positive mood throughout the day and gives you a much-needed energy boost. Besides that, ActivatedYou is also transparent about the strains they used in the manufacture. Hence, you can make sure the product is suitable for you.

Highlighted Features

  • Improves skin health
  • Allows you to stay positive
  • It contains 30 different probiotic strain
  • They are transparent about their products

Gundry MD 24 Strain Probiotic


A poor digestive system can often lead to gas formation in the stomach, making you look more bloated. Thanks to this revolutionary product, you no longer worry about that. Gundry MD 24 Strain Probiotic contains 30 billion CFUs per serving to prevent gas formation and bloating.

The best probiotics can ease the pressure in your intestines and grant you peaceful and uninterrupted sleep. It’s one of the most widely regarded supplements for improving digestive health in men and women. Taking probiotics like this is specifically suitable for you if you are currently on a vegetarian or keto diet.

Additionally, the proven ingredients used in the formulated probiotics don’t induce any significant side effects that can have a toll on your body. It doesn’t contain any caffeine and dairy ingredients either. Multi-strain probiotics also allow you to maintain a bright mood throughout the day by removing stress from your digestive system.

Highlighted Features

  • 30 billion CFU per serving
  • Boosts your mood
  • Suitable for losing weight
  • Reduces gas formation

Unify Health Labs Multi-GI 5


Unify Health Labs Multi-GI 5 is one of the best on this list due to the wide range of proven ingredients it includes. The supplement offers health benefits unlike any other on this list.

Most importantly, the supplement contains 12 unique ingredients that have never been combined before. That’s what sets it apart from regular probiotics. The probiotic is known for revitalizing your gut and maintaining weight throughout your weight loss diet. This makes it much easier to reach your goals.

It keeps your GI lining healthy and nourished to activate your digestive system. With a regular dosage of complete probiotics, you will be able to enhance immune function, which makes you feel more energetic.

The supplement also contains several herbs, minerals, fibers, plants, vitamins, and prebiotics.

Highlighted Features

  • It helps to promote immune health
  • It makes you feel more energetic
  • Keeps your GI lining healthy
  • It contains 12 unique ingredients

Seed Daily Synbiotic


Seed Daily Synbiotic was created to utilize the benefits of bacteria and promote biodiversity. Over the years, they have manufactured some revolutionary products that have helped thousands of people maintain a healthy body. So, you can only imagine how beneficial taking a probiotic can be.

The minimalistic package contains 24 different strains of prebiotics along with probiotics. This makes the probiotics highly efficient at their job. Unlike most probiotics, they can survive stomach acid and enzymes. The probiotics can’t be deterred by moisture or exposure to heat.

Their powerful probiotic formula can help you maintain healthy digestion and prevent gastric issues. The supplement can also enhance cardiovascular health and can support immune health. You can even keep healthy skin and promote micronutrient synthesis in your body.

Highlighted Features

  • 24 different strains of prebiotics and probiotics
  • Probiotics can survive stomach acid
  • Boosts your immune health
  • Allows you to maintain a healthy body by just taking a probiotic

JustThrive Probiotic & Antioxidant


I have one of the best dietary supplements that don’t contain any ingredients that can ruin your current diet. The probiotic supplement supports keto, vegan, and paleo diets, which sets it apart. It also includes some unique bacteria strains that show fascinating results regarding digestive issues.

JustThrive Probiotic & Antioxidant is made out of spore-based probiotics and antioxidants with better survivability. Also, probiotics are 1000 times more efficient than those present in most leading brands. You will get 30 billion colony-forming units with just one serving of Just Thrive Probiotics.

It contains four different strains of probiotics, including HU36 and HU58. The supplement can relieve you of crankiness caused due to sleep deprivation. With low stress, you will sleep much better at night. The probiotic even helps you maintain a healthy immune function.

Highlighted Features

  • It contains HU36 and HU58 bacteria strains
  • Removes crankiness
  • Boosts your digestive and immune health
  • Suitable for keto, vegan, and paleo diets

VitaPost Probiotic 40-Billion


You might have already figured out that VitaPost Probiotic 40-Billion consists of 40 billion colony-forming units per serving. This makes it one of the most potent and diverse probiotics on this list. It contains four specific probiotic strain groups that specialize in tackling different issues in your body.

The manufacturers have made sure each of these strains can work in perfect unison in the formula, making the supplement more efficient at keeping your essential body functions at peak levels throughout the day. It also allows you to maintain just the right amount of beneficial bacteria in your digestive tract.

VitaPost has improved the health of several people worldwide who previously suffered from gastrointestinal issues. With the enhanced immune function, you will also contract lesser diseases.

Its four different strains include Lactobacillus Plantarum, Lactobacillus acidophilus, Lactobacillus paracasei, and Bifidobacterium lactis.

Highlighted Features

  • Protects you from diseases
  • 40 billion CFUs per serving
  • It contains four different strains of probiotics
  • Boosts efficiency of beneficial bacteria

Live Conscious Pro-45


The manufacturers of this popular probiotic supplement have found an efficient way of fueling the probiotic bacteria in your stomach and intestines. Their clever formula gives the probiotics a necessary boost for working at peak levels. This means you will experience significant positive changes in your body after ingesting them.

Live Conscious Pro-45 is one of the most potent probiotic supplements on the market due to its 11 strains of probiotic bacteria. Their formula consists of fructooligosaccharides, or FOS, the main ingredient for healthy probiotics. You won’t find this essential element in other probiotic supplements (at least not in this form).

Live Conscious Pro 45 offers you 45 billion CFUs in a single serving. This is the best way to diversify your gut flora with just a tiny dose. Several users around the world have reported boosted immune function and better digestion. They also disclose all of the ingredients they use in their manufacture.

Highlighted Features

  • 45 billion CFUs per serving
  • Diversifies gut flora
  • It contains 11 different strains of probiotics
  • Contains fructooligosaccharides

Probiotic T-50


Zenith Labs is the company that manufactured Probiotic T-50, which is globally renowned for its powerful and efficacious probiotics. They have several years of research and multiple satisfied customers under their belt. This makes them one of the most reliable probiotic supplements today.

Thanks to their endless knowledge in this field, Probiotic T 50 is the best option for enhancing your immune function. It keeps your immune system active and protects you from most contagious diseases. On top of that, it works as a silent weapon against gas formation in your gut.

Taking probiotic supplements like this also helps reduce bloating caused due to gastrointestinal problems. The supplement provides a healthy ecosystem for your gut bacteria. It also allows you to tackle cognitive issues with an unhealthy gut. Moreover, it is based on a formula made by a doctor, which makes it more reliable.

Highlighted Features

  • Boosts cognitive function
  • Enhances your immune system
  • Provides a healthy ecosystem for probiotic bacteria
  • Removes gas formation

Nuzena Probiotic 40 Gut Boost +


Nuzena Probiotic 40 Gut Boost + is one of the few probiotic supplements suitable primarily for health-conscious vegetarians. That’s because the capsules are made from plant-based ingredients that are vegan-friendly. It also has a unique formula that can increase nutrient absorption in your body.

Most of the nutrients you consume are excreted as waste from your body. By taking probiotic supplements, you can better nourish yourself with the same diet you used to follow. Furthermore, the supplement is capable of reducing bloating and inflammation. You will notice quick relief after taking a probiotic.

The highly-rated probiotic supplement barely costs as much as most probiotic supplements. It can still boost your immune and digestive health more rapidly than any of them. You will receive 40 billion healthy probiotic bacteria with each serving of this revolutionary supplement.

Highlighted Features

  • Controls inflammation
  • Reduces bloating
  • 40 billion live bacteria in each serving
  • Suitable for vegans

UpWellness Probiotic+


If you have used probiotics before then, you must have heard of UpWellness. And if you like how effective their products are, you will be glad to know about this particular probiotic. UpWellness Probiotic+ has explicitly been made to deliver digestive health benefits such as fat loss and reduced bloating.

Those of you on a fitness journey will find this probiotic incredibly helpful. The probiotics quickly dissolve in your bloodstream and boost fat loss within a short time. You will notice significant changes in your weight with regular dosage. People suffering from poor digestion will also find it helpful.

It clears out your digestive tracts and removes gas accumulation. Apart from six different strains of probiotics, the supplement also offers you a sufficient amount of fiber and three natural adaptogenic superfoods. You will also be able to retain a positive mood and sustainable energy if you keep taking regular doses.

Highlighted Features

  • It can support overall digestive health.
  • Supplies you with fiber and three natural adaptogenic superfoods
  • It gives you an energy boost
  • Triggers fat loss quickly

Purality Health Micelle Liposomal Probiotic


After several hours of research and multiple studies, I found the best probiotic strain. The L Rhamnosus is arguably the most beneficial probiotic strains for people with digestive issues. And you will be glad to know that it’s the main ingredient of Purality Health Micelle Liposomal Probiotic.

The manufacturer of these probiotic supplements has modified it to such a level that it gives you the optimum results within a short duration. That’s because they ensure better absorption with the RcME delivery of the probiotics. This makes the good bacteria more efficient and easier to absorb inside the digestive tract.

Moreover, the exceptional probiotic product can tackle multiple digestive issues from different angles. It contains ample amounts of micelle liposomal probiotics along with lactoferrin and an iron-binding protein. This boosts the chances of live bacteria bioavailability in the gut.

Highlighted Features

  • It contains micelle liposomal probiotics
  • Comes with RcME delivery
  • Ensures better absorption rate
  • Has L Rhamnosus probiotic strain

Prime Health Daily Probiotic Balance


I have added another probiotic supplement to this list with an advanced formula to boost fat loss. This is a good and healthy way of tackling obesity without any strenuous exercise routines. It’s one of the few probiotic supplements that use DE111 as an ingredient.

Prime Health Daily Probiotic Balance comes with some other ingredients that can boost regularity in your body. This allows you to recover from poor digestion and urinary tract infections. It also removes the discomfort in your gut by tackling it in various ways. You can even stabilize your immune system and protect yourself from diseases.

Further, the supplement also consists of Lactobacillus Plantarum, Lactobacillus rhamnosus, and Lactobacillus casei. They show incredible effects of weight loss in the average body. With the increased metabolism, you won’t experience any digestive issues in the future if you consider taking a probiotic.

Highlighted Features

  • It contains the rare DE111 strains.
  • Recovers poor digestive system and urinary tract infections
  • Boosts regularity
  • Stabilizes your immune system

Oweli Probiotic


Are you looking for a probiotic supplement to tackle your general health issues? The Oweli Probiotic is just the supplement you need in your daily life. It has the necessary ingredients and several probiotic strains to support a healthy digestive system. Apart from that, it has multiple other health benefits.

This reasonably priced probiotic supplement can also help you manage your weight. It can get rid of constant food cravings, which allows you to maintain a balanced diet. There are no more risks of consuming more calories than you need to. The probiotics in the supplement can help you achieve healthy skin as well.

It can noticeably enhance your immune response and protect you against many disease-causing bacteria. The best probiotic supplement also includes unique ingredients such as fructooligosaccharides and marine polysaccharide complexes.

Lactobacillus paracasei and lactobacillus plantarum are also two of its major ingredients.

Highlighted Features

  • It contains fructooligosaccharides and marine polysaccharide complex
  • Suitable for overall health and wellness
  • Decreases food cravings
  • Complete probiotics promote a healthy gut biome

Earth Echo Probiotic


At number 21, I have included a fantastic supplement filled with 12 potent probiotic strains. These different strains work in concert to deliver maximum digestive health and a rock-solid immune system. This makes it one of the most effective supplements on the list today.

Once you start taking a probiotic, you won’t suffer from digestive issues or be prone to infectious diseases. You will be healthy and thriving for longer. The Earth Echo Probiotic has reportedly decreased cravings in multiple users. On top of that, it can balance your hunger hormones and help you stay fit.

The 12 potent strains of gut bacteria include lactobacillus acidophilus, lactobacillus Plantarum and Bifidobacterium lactis. It also contains some of the best probiotics. These essential nutrients keep your digestive system active and remove stress in your gut, enhancing your mood.

Highlighted Features

  • It contains 12 potent strains of bacteria
  • Reduces food cravings
  • Can support digestive health
  • It consists of Lactobacillus Plantarum and Bifidobacterium lactis

Earth Echo Vitality Bliss Bites


Earth Echo Vitality Bliss Bites are ideal if you don’t like consuming pills daily. It contains 72% cacao, which gives it a genuine chocolaty taste that is impossible to resist. What sets it apart from the others is its delicious chocolate flavor.

You will rarely find any probiotic supplements as easy to consume as this one. It is a highly satisfying way of boosting your gut health daily. With the irresistible chocolate flavor, the only thing you need to worry about is not taking a probiotic more than once a day. The chocolate used in this product is also very organic.

The probiotic is USDA certified and made out of fair-trade cacao, so you don’t need to stress where the chocolate comes from. Moreover, the supplement doesn’t contain any artificial additives or sweeteners. The sweet taste comes from natural coconut sugar and organic insulin.

Highlighted Features

  • Available in delicious chocolate flavor
  • No artificial sweeteners or additives
  • The product is USDA certified
  • It contains 72% pure cacao



This company produces a wide range of probiotic supplements suitable for multiple purposes. They have been in the business for a long time and have conducted several studies to ensure their products are efficient. Probulin is aptly titled “the next generation of probiotic supplements.”

Probulin has numerous beneficial probiotic supplements to tackle different health issues. You will also find products specifically suited for a particular purpose, such as fat loss. One common factor in their products is that they are all good for promoting gut health.

Even some supplements can effectively boost your immunity, which might help you live longer. You can also take a probiotic supplement to give you the energy to sustain an entire day with a smile on your face. Some of its rarer products are known for supporting colon health, unlike any other probiotic.

Highlighted Features

  • Improves the health of your colon
  • It can boost your immunity
  • It helps you reach your fat loss goals
  • Keeps your gut healthy

Microbiome Plus+


If you have weak cardiac muscles and want to reduce your cholesterol levels, Microbiome Plus+ is perfect. The probiotic dosage can lower cholesterol by 11.64% upon daily consumption. This allows you to keep your heart intact for longer, no matter what food you eat.

The probiotic brand has a range of other supplements in its catalog. Some of them are suitable for solving gastrointestinal issues with the help of a few proven ingredients. There are a variety of strains available in their formula that can improve digestion in the long run.

There is an ideal blend of probiotics and prebiotics in their supplements. Microbiome Plus contains a unique strain of probiotics called L Reuteri NCIMB. This strain is proven to increase the efficiency of the probiotics in your gut. Due to this, you will notice faster results and quick changes in your digestive system.

Highlighted Features

  • Reduces LDL cholesterol by 11.64%
  • Contains L Reuteri NCIMB strain
  • Improves the ability of probiotics in your digestive tract
  • Suitable for multiple gastrointestinal issues

Revival Point FloraSpring


Our body is built to absorb most of the calories from our food, which usually leads to fat build-up. We struggle to reach our weight loss goals even after following a strict diet and workout routine. The company Revival Point has manufactured a supplement to tackle the same issue.

Revival Point FloraSpring is targeted to decrease calorie absorption in your body. With low-calorie absorption, you can experience the full effects of your balanced diet without putting in much effort. This supplement can help make the weight loss journey easier for you at a small price.

It will also control your food cravings and focus more on your weight loss goals. The probiotic supplement enhances your metabolism and allows you to stay fit. You can digest all your food without absorbing too many calories with an active and healthy gut.

Highlighted Features

  • Keeps your food cravings in check
  • It helps you lose weight
  • Reduces calorie absorption in your body
  • Increasing your metabolism

Probiotic America Perfect Biotics


If you want noticeable effects in a short time, then you must consider using a probiotic created by the globally renowned Dr. Cary Nelson. His years of knowledge and experience in this sector are enough to ensure the efficiency of his products. They include dozens of different probiotic strains.

Each serving of Probiotic America Perfect Biotics provides over 30 billion CFU that can efficiently tackle your digestive issues. Over the past few years, the company has developed multiple probiotic supplements with different combinations backed by research. The extensive research gives them an edge over their competition.

There are already trillions of bacterial cells present in your body. These supplements improve the efficiency of good bacteria to keep your immune system intact. It also allows you to digest your food much faster and relieves stress from your stomach. Some of the supplements can also heighten your mood.

Highlighted Features

  • Created by Dr. Cary Nelson
  • It contains over a dozen probiotic strains
  • Up to 30 billion CFU per serving
  • Improves the efficiency of good bacteria

Advanced BioNutritionals Advanced Probiotic Formula


Advanced BioNutritionals Advanced Probiotic Formula is one of the most affordable probiotic supplements on my list today, which can solve many digestive issues you might be facing. It’s also one of the most highly rated products today. This supplement is not only good for gut health. It also boosts your memory and helps you make better decisions.

Yes, you heard it right! The probiotic supplement has some unique strains that can boost your cognition, which helps you focus better. It contains other beneficial ingredients that can enhance your overall health as well. If you want to maintain a fit and healthy body even when you grow old, you better take it every day.

The supplement contains proven ingredients like Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium bifidum, and Lactobacillus acidophilus. It also includes a solid prebiotic to balance out the raw probiotics. You will get up to 15 billion CFU with each serving of this efficient supplement.

Highlighted Features

  • It comes at an affordable price
  • It contains 15 billion CFU per serving
  • The supplement can boost your cognition
  • It can enhance your memory

Simple Promise Ovuna


At number 28, I have a fantastic probiotic supplement targeted toward the female audience. Simple Promise Ovuna is made for relieving menopausal symptoms in most middle-aged women. There are barely any supplements on the market that can solve womanly issues as precisely as this one.

We all know how difficult menopause can be for women. These highly effective raw probiotics can prevent annoying symptoms like hot flashes. Some women also tend to put on a lot of weight during menopause. Thanks to Simple Promise Ovuna, you no longer worry about vaginal health.

Sudden food cravings can also be controlled with the help of this supplement. It delivers the probiotics you need to manage your weight. The supplement contains rare ingredients like B breve, L gasseri, B Lactis, and herbal extracts. You will also find antioxidants like turmeric and 15 billion CFUs per serving.

Highlighted Features

  • Suitable for boosting vaginal health during menopause
  • Allows you to manage your weight
  • Can prevent sudden food cravings
  • It contains several herbal extracts and antioxidants

Vital Plan Biome Boost


If you are worried about the side effects of probiotic supplements, there is no better choice than one made from natural herbs. These herbs can improve the efficiency of the microbes in your gut. The Vital Plan Biome Boost contains organic herbs to improve your gut health and boost metabolism.

This supplement is available in a liquid form, unlike most probiotics on the market. That’s why it’s easier to consume than the others. You can mix it with your regular cup of coffee or water and experience the effects throughout the day. However, the most distinguishing feature of this probiotic is some of its unique ingredients.

The probiotic supplement consists of 1920 mg of rare ingredients that aren’t present in most common probiotics. It has a specialized formula with houttuynia cordata plant extract, Cryptolepis sanguinolenta root extract, neem leaf extract, southern prickly ash bark extract, and Chinese salvia root extract.

Highlighted Features

  • Made from natural herbs and ingredients
  • Available in liquid form
  • Boost the efficiency of microbiomes
  • It contains rare ingredients like southern prickly ash bark extract and Chinese salvia root extract.



I have also added a probiotic supplement to this list suited to older people. Most older adults suffer from gut problems that are harder to solve with regular medicine. As you age, your body finds it harder to absorb the necessary nutrients from food. That’s where ProBio-Lite comes in handy.

The ProBio-Lite supplement improves your digestion and your body’s ability to absorb nutrients. This allows you to stay healthy as you age. You get 5 billion colony-forming units every time you consume one of these pills. It supplies your body with good bacteria that keep your gut healthy for longer.

This supplement can also help elders get rid of heartburn and indigestion. This is possible due to all the proven ingredients included in this product. The most contributing ingredients are Lactobacillus salivarius, Lactobacillus acidophilus, Lactobacillus Plantarum, and Bifidobacterium lactis.

Highlighted Features

  • A supplement suitable for old people
  • Can reduce heartburn
  • Delivers 5 billion CFU per serving
  • It contains Lactobacillus salivarius and Lactobacillus acidophilus



Orthobiome is another probiotic supplement on this list that doctors have formulated. Several satisfied customers have widely regarded the product manufactured by the Healthy Living Association company. It contains nine different probiotic strains that can boost your digestive health in a few days.

The supplement is also highly beneficial for anxiety patients and those who suffer from constant mood swings. Most people don’t know that these problems are often caused due to poor gut health. The supplement contains ingredients that can relieve gastrointestinal stress.

Additionally, probiotics can remove stubborn fat from your abdomen and help you control your appetite. Orthobiome can also allow you to lose weight. It can effectively reduce bloating by stopping gas formation in the stomach. Moreover, you can experience all these benefits without emptying your pockets every month.

Highlighted Features

  • It helps you control your appetite
  • Reduces lower abdomen fat
  • Instant relief from gastrointestinal stress
  • It contains nine different probiotic strains

Organixx Probiotixx +


Many people can’t eat properly due to the gas formation in their stomachs. This makes them appear bloated and damages the health of your gut. If you are looking for instant relief from gas and bloating, Organixx Probiotixx + will do wonders. Thanks to this product, you can remove the gas in a few days.

Probiotics can get rid of stubborn fat when you are on a balanced diet. Moreover, this efficient probiotic supplement can trigger weight loss in a short amount of time. You can lose up to 10 lbs in months without going to the gym. This can help you achieve a fit body without much effort.

Organixx Probiotixx has also shown incredible results in enhancing mental clarity. This ensures better focus, whether at work or during day-to-day activities. This supplement will get a strong dose of the Lactobacillus Plantarum strain and 2.5 billion CFU per serving.

Highlighted Features

  • It contains a strong dose of Lactobacillus Plantarum strain
  • It gives you 2.5 billion CFU per serving
  • You can lose up to 10 lbs in a few weeks
  • It prevents gas formation in the stomach

PhytAge Labs Replenish 911


PhytAge Labs Replenish 911 contains ten different probiotic strains working in unison to reduce digestive issues. Also, this product helps you reach your desired body. The product is also a contributing factor to long-term weight loss. Many users have reported losing between 10 and 34 pounds in just a matter of weeks.

The supplement also consists of antioxidants and a proper balance of probiotics and prebiotics. This enables you to replenish your gut health and diversify gut flora. Apart from that, it’s one of the most popular probiotic supplements on the market that can get rid of stubborn fat.

This supplement has several essential ingredients to improve your gut health and solve multiple digestive issues. It can also eliminate the gas in your intestines, making you feel less bloated. With this incredible supplement at your disposal, you can even keep your inflammation in check.

Highlighted Features

  • It contains ten different probiotic strains
  • It helps you lose up to 34 lbs of fat
  • Keeps inflammation in check
  • Reduces gas and bloating

Vital Plan Advanced Biotic


As the final product on this list of reviews, I have added a probiotic supplement made by the famous Dr. Bill Rawls. He made Vital Plan Advanced Biotic precisely to balance the microbiome in your body and enhance gut flora. The supplement is filled with natural herbs that have proven effects on improving gut health.

It also contains cat’s claw extract, sarsaparilla, Japanese knotweed extract, berberine, and garlic. Although this doesn’t consist of probiotics like the other products on my list, it can still boost the probiotics’ efficiency in your digestive tract.

Some of you might be wondering why you should choose a supplement that doesn’t even contain probiotics. The answer is simple. This product contains natural plant and herb extracts that can effectively boost your immune system. They are also capable of enhancing your digestive functions in the long run.

Highlighted Features

  • Made by Dr. Bill Rawls MD
  • It contains natural ingredients like cat’s claw extract, sarsaparilla, and Japanese knotweed extract.
  • Boosts your immune system
  • It makes the probiotics in your body more efficient

The Top Probiotic Supplements in 2022 Final Words

If you have read through the entire article, you are well equipped to buy the best probiotic supplements that can diversify gut flora. Make sure you only rely on the products that offer the benefits that you seek. Purchasing any other supplement for problems you don’t have might be unwise and costly.

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